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In addition to prevention of apoptosis, myricetin reduces the HG-induced increase in lipid peroxidation levels, Bax and Bcl-2 expression levels, cleaved caspase-3 levels, suggesting that myricetin significantly lowers the risk of T2DM progression through protection of endothelial cells (43)

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The SELECT trial, completed in 2023 with over 17,600 participants, showed a 20% reduction in cardiovascular events in patients with established cardiovascular disease and overweight or obesity without diabetes

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