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Its not just FOXO4-DRI that has this problem many senolytic therapies starting human trials have barriers to cross: there are still lingering unknowns with regards to their effectivity as therapies

Pediatric Neurol

In summary, these data provide evidence that long-term IGF-1R blockade with mAbs is feasible, well tolerated, and can recapitulate effects observed with genetic disruption of IGF-1R signaling on lifespan

Beneficial effects of BBR in the treatment of diabetic complications DM could lead to a variety of complications such as encephalopathy, hypertension, neuropathy, retinopathy, nephropathy, as well as memory impairment (Deng et al., 2023)