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Rinaman explained that when GLP-1R agonist drugs are given systemically, they are not recruiting the central GLP-1 endogenous neurons but are accessing a subset of the receptors

Zepbound also has the added benefit of being combined with a glucose-dependent insulinotropic polypeptide receptor agonist (GIP RA)

The body has a drive towards balance, especially at the cellular level

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doi:10.1016/S2213-8587(24)00155-4 33

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