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First, SELECT was not a primary prevention trial, and the data should not be extrapolated to all individuals with overweight and obesity to prevent major adverse CV events

Also, Wegovy must not be given to people with a personal or family history of multiple endocrine neoplasia syndrome type 2 (MEN 2) or medullary thyroid carcinoma (MTC)

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Zhu W, Zhong C, Yu Y, Li K: Acute effects of hyperglycaemia with and without exercise on endothelial function in healthy young men

The weight loss it supports is itself a significant cardiovascular benefit, since excess weight is a major risk factor for heart disease