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Other conditions in which neurogenic inflammation may be implicated include irritable bowel syndrome, vulvodynia, migraines, and fibromyalgia, conditions that frequently overlap with IC/BPS

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As put by the authors of a 2019 review on drug-phospholipid complexes, the combined affinity for fats and water means that phospholipids function as emulsifiers that enhance absorption and, therefore, bioavailability.4 Indeed, a 1990 human study found that a silymarin-phospholipid complex resulted in plasma levels of silybin (silymarin's main active component) that were more than double the amount provided by an equal quantity of pure silymarin 298ng/mL versus 102ng/mL per 120mg of silybin.34 Given the science behind phospholipid-based drug delivery, we can conclude that Life Extension is likely capable of delivering more per-dose silymarin, as well as isolated silybin, than either NOW or HUM (neither of which uses phospholipids)

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