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For combination therapy (CagriSema), the cagrilintide component is 2.4 mg weekly paired with semaglutide 2.4 mg

Common side effects may include: Increased hunger Water retention and joint stiffness Tingling or numbness in the extremities (carpal tunnel syndrome symptoms) Muscle aches Insulin resistance (a significant consideration that requires monitoring) Crucial Warning: The long-term safety of combining these peptides is not well-studied

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(2009) Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology

4 FDA Compounding Policy: Category 1 peptide reclassification, February 2026