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The reversal of NET function results in efflux of cytoplasmic norepinephrine, normally contained in the , readily releasable pool 2) into the synaptic cleft, independent of calcium influx and the normal process of vesicular release (Raiteri and Levi, 1986

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Conversely, over drugged ADCs often exhibit increased aggregation and have been associated with increased toxicity

For instance, changes in microbiome composition can trigger molecular cascades that contribute to atherosclerosis, dyslipidemia, and obesity [106]