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Phase 2 data (Jastreboff et al., NEJM 2023) showed mean pulse rate increases of approximately 3 to 5 beats per minute at higher doses, consistent with known GLP-1 receptor agonist pharmacology
The statement suggests that the patient's liver enzymes were elevated, which often indicates damage to cells in the organ and is an issue that has been linked to some other obesity drugs
Experiments running for several weeks or months require a stable compound
Followup to monitor response, side effects, and dose titration
Ertekin-Taner, A
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