The program includes four Phase 3 trials: TRIUMPH OB (obesity), TRIUMPH OB-D (obesity with type 2 diabetes), TRIUMPH NAS (non-alcoholic steatohepatitis), and TRIUMPH OA (osteoarthritis with obesity)
Advise patients that the most common side effects of semaglutide are nausea, vomiting, diarrhea, abdominal pain and constipation
The cardiovascular benefits observed with these medications include: Reduction in non-fatal myocardial infarction and stroke Decreased cardiovascular mortality in high-risk populations (demonstrated with liraglutide) Improvements in blood pressure and lipid profiles Weight reduction , which independently lowers cardiovascular risk It is important to distinguish between arterial thrombotic events (such as heart attacks and strokes, which some GLP-1 agonists help prevent) and venous thromboembolism (DVT and PE)
Epitalon in Use In most cases, Epitalon is available in the form of injections or oral supplements
doi: 10.1002/jcp.24395 242 SantoroA.CalvoJ
Am J Health Syst Pharm 70(17):14831494