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Under an energy deficit (that is, hunger) state, synaptic strength is weaker but is more profoundly augmented by GLP-1R activation than under energy-replete state

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Stamatiades, G

If you're searching for info about PCOS and weight loss, it's probably because you've felt frustrated by slow progressor by losing weight, only to gain it back despite doing literally everything right

Neurosci Biobehav Rev 29:891909 Dwivedi Y (2009) Brain-derived neurotrophic factor: role in depression and suicide