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There is no strong clinical support that they permanently increase girth, and improper technique can cause bruising, pain, scar tissue, nerve injury, or erectile dysfunction

Biomarkers for the diagnosis of ALS and the assessment of upper motor neuron abnormality in the early phase are limited, but neuroimaging techniques such as advanced magnetic resonance imaging (MRI) provide increasing insights into the pathophysiology of ALS (Wang et al., 2011)

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