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Investigations showed a normal chest radiograph/chest X ray (CXR), and spirometry showed moderate obstruction with FEV1 reversibility of 21% (but not back to normal) and even some air-trapping with FVC that improved by 19% with bronchodilator

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Study design This was a randomized, double-blind, placebo-controlled, matched-pair study

For decades, the pharmaceutical approach was to suppress glucagon activity in diabetes patients

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This pharmacologic property distinguishes it from small-molecule therapeutics where hepatic impairment dramatically alters drug-drug interaction profiles