Apothionein, also known as zinc-free MT, has the ability to remove zinc from p53, leading to a reduction in its transcriptional activity and subsequently suppressing its DNA binding capabilities
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It can also be beneficial for patients requiring hydration for certain medical procedures, such as surgery or chemotherapy
After treatment, cells were washed 3 with PBS, trypsinized, and resuspended in 200 L of PBS
17 HongL.KimI
However, pure MDM4 inhibitors and MDM2/4 bispecific inhibitors are lacking, and further exploration of new effective drugs is still needed