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The potent weight loss induced by GLP-1MK-801 was linked to a potentiated decrease in food intake in mice treated with GLP-1MK-801 compared to mice treated with vehicle or GLP-1 or MK-801 monotherapies (Fig

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More serious risks include pancreatitis, gallbladder disease, acute kidney injury, and a boxed warning for thyroid C-cell tumors (with a contraindication in patients with personal/family history of MTC or MEN2)