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doi: 10.1038/s41590-021-01104-y 6 BakamutumahoBCummingsMJOworNKayiwaJNamulondoJByaruhangaTet al

Regulatory and Ethical Context The FDA has approved recombinant human IGF-1 only as mecasermin (Increlex) for the narrow indication of severe primary IGF-1 deficiency or GH-gene deletion with neutralising antibodies to GH, in children [15]