Limited Long-Term Data Mounjaro only approved in 2022 Zepbound only approved in 2023 Long-term safety profile still emerging Unknown effects of decades-long use 2
Gradual titration is essential: Opening at 2 mg weekly instead of a higher dose markedly lowers the odds of early gastrointestinal effects [4]
Beyond that, the supplements guide for GLP-1 users recommends considering: Electrolytes: Especially during the first few weeks when GI side effects are most prevalent B12: Often combined with GLP-1 agonists in compounded formulations, as semaglutide with B12 and tirzepatide with B12 combinations demonstrate Fiber: To support digestive regularity, which can be disrupted by altered gastric motility Biotin: Particularly if hair thinning occurs, as a preventive measure alongside adequate protein Exercise during retatrutide use Resistance training is more important than cardio during a GLP-1 protocol
Theres a small amount of research that suggests certain teas, like green tea and yerba mate , may increase GLP-1 levels
Lincoff, who serves as co-principal investigator of the study
A., Wood R., Leith A., Piercy J., Higgins V
