Proc Natl Acad Sci USA 1995;92:81159
Rotation is mandatory for any protocol lasting more than a few days
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Fella prescribes compounded semaglutide and tirzepatide
The pivotal trial, STEP 1, randomized 1,961 adults with a BMI of 30 or higher (or 27 with a weight-related comorbidity) to weekly semaglutide 2.4 mg or placebo, both alongside lifestyle counseling
A salt-form theory may be chemically plausible
