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2.2 Circadian disruption as a driver of metabolic liver disease Growing evidence suggests that circadian disruption is a critical risk factor for the development and progression of MASLD (7, 32)

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Stratified by different indications For indication of obesity alone, AOMs resulted in 1.31 kg (95% CI 0.38 to 2.24, P = 0.006, I 2 = 73%) weight regain compared with control groups

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