Creatine monohydrate: Occasionally used to support muscle retention and exercise performance during caloric restriction
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The TRIUMPH-4 safety profile is qualitatively similar to semaglutide and tirzepatide (GI adverse events dominate) but the rate of nausea, vomiting, and diarrhea is higher than previously seen in the class, and dropout at 12 mg is higher than at 9 mg
Those on GLP-1s are advised to eat a high-protein diet and regularly exercise, including strength training, to minimize muscle loss
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