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Its efficiency in ubiquitination, LC3-II-mediated encapsulation, and the timing of autophagosome-lysosome fusion collectively determine the rate of mitochondrial clearance [103]

Systemic injection of human ExerVs prevents collagen I accumulation during hindlimb unloading Human EVs were systemically administered to mice during 14 days of HU (Fig

18 BLM induced the upregulation of Col12, Col31 and Col4a2 mRNA expression compared with control, and FOXO4DRI repressed BLMinduced upregulation of the above genes similar to PFD group (Figure 1E)

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