The mechanism through which it promotes fat loss, primarily beta-3 adrenergic receptor activation, is completely separate from IGF-1 signaling
93 In contrast, markers of mineral metabolismincluding 25-hydroxyvitamin D, bone-specific alkaline phosphatase (BALP), and PTHremain largely stable over the long term, 94 suggesting that VSG-mediated skeletal remodeling occurs independently of traditional calciumphosphorus regulatory pathways
PMCID: PMC10667917
Injecting too close to the belly button or other sensitive areas can also cause discomfort
Most GLP-1 side effects are gastrointestinal, mild, and improve within the first few weeks of each dose level Serious warning signs severe abdominal pain, persistent vomiting, or allergic reactions are rare but require immediate medical attention Wegovy, Zepbound, and Foundayo share a similar GI side-effect profile, with some differences in nausea and diarrhea frequency In-person monitoring at PEAK allows your clinician to catch issues early and adjust your titration schedule in real time Starting a GLP-1 medication like Wegovy (semaglutide), Zepbound (tirzepatide), or Foundayo (orforglipron) is a major step toward better health and it is completely normal to wonder what to expect along the way
However, they work in different ways and are suited to different skin types