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To interrogate this, we have developed a series of in vivo models to induce Gclc deletion in adult animals

The primary outcome was change in overall symptoms, measured using standardized rating scales such as the YaleBrown Obsession Compulsion Scale [16], the Massachusetts General Hospital Hair Pulling Scale [17], and the YaleBrown ObsessiveCompulsive Scale Modified for Neurotic Excoriation [18]

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In various pathological conditions implicating oxidative stress, ER functions are disturbed resulting in ER stress and initiation and propagation of unfolded protein response (UPR), which results in transient suppression of protein translation to allow recovery but leads to cell death when stress cannot be resolved (Soliman et al., 2019)

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