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Further, the ability of GLP-1 to suppress feeding, an action dependent upon CNS receptors, is blunted in fasted conditions (159, 243) and dependent upon nutrient-dependent intracellular pathways (88) indicating that CNS GLP-1r signaling is also dependent upon nutrient availability

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doi: 10.1046/j.1523-1747.2000.00061.x

PMID: 40129870 iScience 2026 Jun 13;29(7):116323

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