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Step 2: Eliminate the Trigger If the dark spots are linked to an external factor, that factor must be removed first

Barnard ND, Holtz DN, Schmidt N, Kolipaka S, Hata E, Sutton M, et al

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In SURMOUNT-1, adults with obesity (without diabetes) lost an average of 15.0%, 19.5%, and 20.9% of body weight with tirzepatide 5 mg, 10 mg, and 15 mg respectively over 72 weeks, compared to 3.1% with placebo

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In this study, the results of flow cytometry, immunofluorescence staining, RT-qPCR and ELISA assays demonstrated that GLP-1RAs could drive macrophage polarization towards the M2 type, thereby inhibiting the continuous development of synovitis