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The standard approach is to probability-weight the exclusivity cliff: assign a probability to each listed patents survival through the litigation period and calculate the expected loss-of-exclusivity date as a probability-weighted average across the patent portfolio

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CrossRef Evodiamine targets ZO-1 to ameliorate cholestatic liver disease: Intestinal homeostasis as the core mediator of gut-liver axis repair and bile acid metabolism remodeling Shuxin Yan, Yao Zhang, Qiqi Fan, Wenwen Jia, Yihang Dai, Xinlin Li, Shan Lu, Yuhan Sheng, Shuang Sun, Ruichao Lin, Yang Tang, Chongjun Zhao Phytomedicine .2026