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The adipocyte secretes over 50 cytokines and hormones that both enhance and suppress inflammation, secretes extracellular matrix proteins that impact inflammation, produces and releases toxic lipids that aggravate inflammation, and, more recently, was shown to present antigen to activate CD4+ T cells

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These hormones act as inactive precursors of oestradiol (E2) and testosterone (TT), which are converted locally in peripheral tissues via intracrinology [141]

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Notably absent from areas of active demyelination are significant numbers of lymphocytes, and any lymphocytic infiltrates that were present were distant from regions of myelin and axonal injury (Machado-Santos et al., 2018)

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