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Type 2 diabetes is usually managed with metformin, and long-term metformin use is one of the clearest medication-related causes of low B12 in the UK

1994 Mar;106(3):615-23

But if you have enough of it, there is no clear indication that the vitamin helps in weight loss

However, similarly to vitamin K, certain water-soluble vitamins have no observable toxicity and hence no set UL

Less common but serious side effects include pancreatitis, gallbladder issues, and (in rare cases) thyroid tumors in patients with a personal or family history of medullary thyroid cancer or MEN-2

0.16 ng/ml/12 ml/day till the sacrifice) and intragastrically after cuprizone instilations, while controls received simultaneously drinking water only (12 ml/day) as well as an equivolume of saline (5 ml/kg) intragastrically after cuprizone instillations