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Among those who felt they needed to self-medicate, the main reasons given were to improve fatigue and to reduce brain fog and pins and needles

doi:10.1093/ajcn/74.2.233

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There's no safety data for use during pregnancy or lactation

It was found that there was an increased predisposition to develop glucose intolerance or T2D, and that this change was independent from IGFBP-1 [208]