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Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. In semaglutides extension, about two-thirds returned within one year. The pattern reflects removal of appetite suppression after major weight loss

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461 Conversely, interventions such as caloric restriction enhance autophagy, improve remyelination, and reduce disease severity in relapsing-remitting MS, emphasizing its therapeutic potential when properly modulated