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A small, measurable amount of APAP (2%) is excreted in the urine without having undergone any metabolism

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References: Office of Dietary Supplements, National Institutes of Health

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Around the period of Earth's transition from anaerobic to aerobic conditions about 2.4 billion years ago (bya), the evolution of SOD enzymes crucially allowed organisms to overcome the effects of oxidative stress following the surge of molecular oxygen (O 2 ) in the atmosphere (Miller 2012)