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The FDA does not recognize HCG as safe or effective for weight loss, and any claims linking HCG to fat reduction remain anecdotal

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In 2025, a joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society suggested that patients on GLP-1 drugs consider a multivitamin-mineral supplement, flagging nutrients of concern including vitamin D, B12, iron, calcium, magnesium, and zinc

J Health Econ (2004) 233:56587

Loss of color may indicate copper dissociation