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Mentz RJ, Anker SD, Pitt B, et al

Mix the powder with a carrier oil, such as coconut oil, or moisturizing cream, and apply it directly to the skin

Because this is a pre-blended mixture, your solvent volume calculations must factor in the volume displacement of a larger total powder volume to ensure exact delivery metrics during micro-pipetting procedures

(A from Goldman MP et al: Arch Dermatol 123:1196, 1987.) Figure 7.16 Fibrous cord formation is present 30 days after injection of polidocanol 1.0%