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Since treatment with exendin-4 only modestly lowered cholesterol level and affected lipoprotein profile of the mice, anti-atherogenic effect was independent of modulation of plasma lipid levels and dependent on anti-inflammatory response

The latter include synaptic protection, improvements in cognition, learning and motor function, amyloid pathology-ameliorating properties (A, Tau, and -synuclein), the suppression of Ca 2+ deregulation and ER stress, potent anti-inflammatory effects, the blockage of oxidative stress, mitochondrial dysfunction and apoptosis pathways, enhancements in the neuronal insulin sensitivity and energy metabolism, functional improvements in autophagy and mitophagy, elevated BDNF and glial cell line-derived neurotrophic factor (GDNF) synthesis as well as neurogenesis

Deubiquitinating enzymes (DUBs) represent an additional regulatory layer with therapeutic potential

Data was deemed significant at p 0.05

PXN, a less-studied metabolite of CAF, has distinct pharmacokinetic and pharmacodynamic properties (Lelo et al