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67 Additionally, the Toll-like receptor 4 (TLR4)/NADPH oxidase 4 (NOX4) pathway plays a role in heart failure associated with ferroptosis

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2023 Mar 30;97(3):e0001623

Methods accounting for differences in randomization ratios and study-level cardiovascular risk Due to the asymmetric randomization ratios and patient populations with different cardiovascular risk across the trials, the crude estimates simply aggregating the trials on each of the pooled tirzepatide group and the pooled comparator group could be misleading