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The phase 2b ENLIVEN trial, a multicenter, randomized, double-blind, placebo-controlled study, included 222 patients with biopsy-confirmed NASH and F2-F3 fibrosis, assigned to receive pegozafermin at doses of 15 mg weekly, 30 mg weekly, 44 mg every 2 weeks, or placebo for 24 weeks

Authors demonstrated that the novel peptide inhibitor of DPP-IV (Tyr-Pro-D-Ala-NH 2 ) blocks DPP-IV activity and attenuates acute, semi-chronic, and relapsing TNBS- and DSS-induced colitis in mice after topical administration (Salaga et al

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Chronic stress has been associated with releasing stress hormones such as cortisol, contributing to oxidative stress and inflammation

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