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To assess the efficacy of combination treatment, tumour-bearing mice were treated as above with 5FU + metformin and CC3-quantified, showing an increase in average cell death per tumour per mouse with combination treatment (Extended Data Fig

Taurine, calcium, magnesium, and sodium round out the formula for cellular hydration and electrolyte support

The Nrf2/HO-1 pathway plays a vital role in antioxidative and iron-homeostatic responses, exhibiting a well-documented double-edged sword effect in ferroptosis regulation

Studies report improvements in insulin resistance, measured by HOMA-IR, along with reductions in basal insulin levels