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The paper reported on the remarkably high rate of favorable responses we have seen from ad hoc use of such drugs in the cases presented here of MCAS

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This combinatorial approach may ultimately prove more flexible than the all-in-one triple-agonist strategy, because it allows each component to be dosed independently and titrated to individual response

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Their estrogen levels amplify GLP-1 sensitivity, their metabolic flexibility (the ability to switch between burning fat and carbohydrates) is at its peak, and their muscle mass relative to body weight supports thermogenesis