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Reduced oxygen delivery pushes follicles toward premature shedding

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GPX4 is the primary endogenous defense mechanism against lipid peroxidation, while CoQ10 provides secondary protection against lipid peroxidation-induced ferroptosis

2,28-30 Genetic perturbation of these enzymes can, therefore, block cell death under ferroptosis-inducing conditions by eliminating the key substrate (i.e., PUFA-containing lipids) required for the execution of this process