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A Spectra Systems FL2000 fluorometer (Spectra Physics, Mountain View, California, USA) was used for detection, with excitation and emission at 394 and 480 nm, respectively

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Notably, rather than accurately fitting the experimental results, the main purpose of this model was to demonstrate how a calciummediated feedback inhibition in the GPCR signaling pathway can robustly explain an array of sensory responses: It enables pulsatile activity as well as adaptation to the first derivative of the gradients

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