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One hypothesis is that GIP activation enhances energy expenditure and lipolysis in adipose tissue, counteracting its lipogenic effects when combined with GLP-1 activation
A critical step in mitochondrial apoptosis is the mobilization of cytochrome c from IMS
Moreover, a phase 3 trial involving 800 participants with MASH-related fibrosis (F2-F3) showed that weekly semaglutide 2.4 mg compared with placebo was associated with significant MASH resolution and potential improvement in liver fibrosis [98]
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