Once in circulation, GLP-1 is rapidly degraded by DPP-4, which cleaves the active hormone to form GLP-1(9-36) with significantly reduced insulinotropic activity
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During these episodes, the person will feel a loss of control over their eating and may not be able to stop even if they want to
Animal research suggests that intestinal NAD+ biosynthesis is required for the gut to produce GLP-1 naturally, though human data is still emerging
The concept of microdosing reportedly dates back to the 90s, when it was part of clinical drug development, before it was adopted by psychedelics users (and then GLP-1 users)
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