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Zhang, L., Xu, F

However, independent lines of evidence continue to support involvement of FNDC5/irisin signaling in metabolic adaptation, bone remodeling, and neuroprotection, suggesting that early technical limitations may have obscured rather than invalidated its physiological relevance (Perakakis et al., 2017)

doi: 10.1016/j.jaad.2014.12.013 70

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And not every source of niclosamide is equal in polymorphic structure, solubility, and therefore in vivo therapeutic performance