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G2019S is the most common variant in Europe and North America, accounting for 4% of familial PD and 1% of sporadic PD (Healy et al., 2008), while in Asia this variant is rare but prominent allelic heterogeneity was observed (Foo et al., 2017, 2020)

Mitochondrial ROS inactivate redox-sensitive tyrosine phosphatase PTP1B, enhancing TGF- receptor phosphorylation [381]

The first firm proof of dynamic DNA methylation in the adult brain came from a seminal study by Miller and Sweatt (2007), who investigated DNA methylation in the CA1 region of the hippocampus (see Figure 2) and its role in memory consolidation

Ferroptosis: regulated cell death