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PT-141 should only be used as needed and not more than 8 times per month

Data are expressed as the mean SEM

Histopathologically, imatinib-induced oral pigmentation usually presents as spherical pigmented melanin bundles in the lamina propria, with no sign of inflammation or haemorrhage [3, 18,19,20, 23]

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This activation plays a crucial role in regulating peristalsis (the contraction and relaxation of muscles in the gastrointestinal tract), enhancing secretion, and modulating sensory transmission between the gut and the central nervous system [63]