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Initially, patients have a thyrotoxic phase, later passing through euthyroidism to hypothyroidism and, finally, return to euthyroidism

Additionally, agents capable of positively modulating more than one peptide hormone receptor simultaneously, such as tirzepatide or the recently characterised GL-0001 peptide, could offer an even more exciting avenue to help realise the potential of gut-derived hormones to treat bone disease

Reduction of GSSG to two moles of GSH is the function of glutathione reductase, an enzyme that requires coupled oxidation of NADPH

The overall appetite suppression remains substantial regardless of cycle timing

The rate-limiting enzyme, 4-hydroxybenzoate polyprenyltransferase, regulates the elongation of the side chain to ten isoprene units, which is characteristic of human CoQ10 (Shi et al., 2025)