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Door de koppeling aan een acetylgroep kan deze vorm gemakkelijker door celmembranen bewegen en de bloed-hersenbarrire passeren

Bilateral and symmetrical symptoms : Numbness affecting both feet or both hands in a "glove and stocking" distribution may suggest diabetic peripheral neuropathy or nutritional deficiency, both of which require investigation and management

In summary, while the reviewed clinical studies provide encouraging signals, they suffer from small samples, heterogeneous populations, non-standardized endpoints, and short durations