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Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice

The combined receptor engagement produces greater reductions in caloric intake and improved insulin sensitivity compared to GLP-1 agonism alone [2]

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Mutagenesis of Glu 127 resulted in a sevenfold reduction of Ex4(9-39) affinity but with no effect upon GLP-1, suggesting it may be responsible for the differential affinity of these peptides at the NTD (Underwood et al ., 2010)