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Among the pathogenesis-oriented therapies, ALA, actovegin, benfotiamine, and epalrestat are currently authorized for the treatment of DPN in several countries [71,110,192]

Indeed, anorexic or anorectic agents suppress appetite and reduce body weight, via acting on the satiety centre in the central nervous system, hypothalamus and altering crucial pathways in the neuroendocrine system as well as the brain-gut connection

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The information presented reflects allegations made in ongoing litigation and does not represent established findings of fact or law

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