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Unlike conventional biochemical assays using red blood cell (RBC) haemolysates or recombinant enzymes that require specialized systems and laborious purification 21 , LEICA calls for only a single gene replacement (and variants therein) with a straightforward growth measurement, as all the necessary substrates and cofactors are present in live bacteria
Strong regulatory oversight ensures high standards in cold-chain logistics, supporting safe distribution of injectable therapies
it is likely to translate into better real-world adherence, and better adherence is the most important determinant of long-term therapeutic outcomes in chronic disease management
The other virus-targeting agents have varying effects on HBsAg and HBV DNA, depending on the drug mechanism
We now have randomized controlled trial data from 2024 and a prospective substudy from 2025 documenting measurable changes in both
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