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Recent randomized double-blind trials showed that treatment with GLP-1R agonists reduces cardiovascular events, stroke, and nephropathy 8,9
November 21 Product: Jazz and Zymeworks Ziihera Indication: HER2-positive biliary tract cancer With the FDAs approval of Ziihera on Thursday, Jazz Pharmaceuticals and Zymeworks will go toe-to-toe with AstraZeneca and Daiichi Sankyo, whose antibody-drug conjugate Enhertu (fam-trastuzumab deruxtecan-nxki) was given a broad tumor-agnostic approval in April 2024
To generate novel information about the functional pathways represented by these potential GLP-1R interactors, we performed pathway enrichment analysis with the GLP-1R binding partners exhibiting changes between vehicle and exendin-4-stimulated conditions using gProfiler
While often dismissed as just getting older, these changes are frequently linked to a decline in hormones
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To further explore the biological implications, the investigators carried out functional enrichment analyses
